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Document 2721
DOCN M94A2721
TI HIV-1 incidence in adults and risk factors for seroconversion in a rural
population in Uganda: 3 years of follow-up.
DT 9412
AU Kengeya-Kayondo J; Kamali A; Nunn AJ; Malamba S; Wagner HU; Mulder DW;
Medical Research Council AIDS Programme, Entebbe, Uganda.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):24 (abstract no. 068C). Unique
Identifier : AIDSLINE ICA10/94369854
AB OBJECTIVES: To determine over a three year period the HIV-1 incidence
and to study risk factors associated with seroconversion in a rural
population cohort. METHODS: A cohort of approximately 10,000 persons in
a rural sub-county of S-W Uganda was enrolled in 1989-90 through
sociodemographic and serological surveys which were repeated annually
over a three year period. Serostatus was determined using two
independent ELISA assays and western blotting when appropriate.
Incidence rates were calculated per 1000 person years. Intervention
efforts in the area include behaviour change messages and limited condom
distribution. RESULTS: At the time of enrolment the overall prevalence
of HIV-1 infection in the adult population was 8.2%. During three years
of follow-up, the incidence of HIV-1 infection in adults (aged 13 yrs or
more) was 6.2 (95% CI = 4.6 to 7.7). Although rates were highest in
those aged 25-34 years (9.4), this was not significantly different from
those aged 35 or more (6.6; p > 0.2); neither was the difference between
males and females (6.5 and 5.9 respectively; p > 0.2). Annual incidence
rates by calendar year declined from 7.5 in 1989/90 to 4.6 in 1993 (p >
0.2). Non-Muslims had a higher risk than Muslims (8.2 vs 3.9 p = 0.07)
as did non-Baganda compared to Baganda (9.4 vs 6.0). Persons who had
moved to their present residence less than 10 years previously were
twice as likely to seroconvert than those who had been at their
residence for longer (11.0 and 4.8 respectively; p < 0.04). CONCLUSIONS:
In this rural population with a considerable HIV prevalence, incidence
rates appear to be declining with only modest intervention efforts and
are similar for different age groups. Special AIDS prevention efforts
are needed to reach recent immigrants and to communicate better with
minority tribes.
DE Acquired Immunodeficiency Syndrome/*EPIDEMIOLOGY Adolescence Adult
Cohort Studies Ethnic Groups Female Human HIV
Seropositivity/*EPIDEMIOLOGY *HIV-1 Incidence Male Prevalence Risk
Factors Rural Population Uganda/EPIDEMIOLOGY MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).